Recent publications

2020

Can immobilization of an inactive iron species switch on catalytic activity in the Suzuki reaction?

S. B. Tailor and R. B. Bedford, Catal. Lett., 2020, 150, 963–968

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2019

Methylenespiro[2.3]hexanes via Nickel-Catalyzed Cyclopropanations with [1.1.1]Propellane.

S. Yu, A. Noble, R. B. Bedford* and V. K. Aggarwal,* J. Am. Chem. Soc., 2019, 141, 20325−20334.

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Revisiting Claims of the Iron‐, Cobalt‐, Nickel‐, and Copper- Catalyzed Suzuki Biaryl Cross-Coupling of Aryl Halides with Aryl Boronic Acids.

S. B. Tailor, M. Manzotti, S. Asghar, B. J. S. Rowsell, S. L. J. Luckham, H. A. Sparkes and R. B. Bedford, Organometallics 2019, 38, 1770−1777.

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The surprisingly facile formation of Pd(I)–phosphido complexes from ortho- biphenylphosphines and palladium acetate.

M. Montgomery, H. M. O’Brien, C. Méndez-Gálvez, C. R. Bromfield, J. P. M. Roberts, A. M. Winnicka, A. Horner, D. Elorriaga, H. A. Sparkes and R. B. Bedford, Dalton Trans., 2019, 48, 3539–3542.

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The highly surprising behaviour of diphosphine ligands in iron-catalysed Negishi cross-coupling

Antonis M.Messinis, Stephen L. J.Luckham, Peter P. Wells, Diego Gianolio, Emma K.Gibson, Harry M. O’Brien, Hazel A. Sparkes, Sean A. Davis, June Callison, David Elorriaga, Oscar Hernandez-Fajardo and Robin B. Bedford, Nature Catalysis, 2019, 2, 123-133.

2018

Iron-catalysed substrate-directed Suzuki biaryl cross-coupling
Harry M. O’Brien, Mattia Manzotti, Roman D. Abrams, David Elorriaga, Hazel A. Sparkes, Sean A. Davis and Robin B. Bedford, Nature Catalysis, 2018, 1, 429-437. 

2017

Cobalt-Catalyzed Suzuki Biaryl Coupling of Aryl Halides

S. Asghar, S. B. Tailor, D. Elorriaga and R. B. Bedford, Angew. Chem. Int. Ed. 2017, 56, 16367 –16370

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Isoindolinones via Copper-Catalyzed Intramolecular Benzylic C–H Sulfamidation

R. B. Bedford, J. G. Bowen, C. Méndez-Gálvez, J. Org. Chem., 2017, 82, 1719–1725

isoindolinones

2016

The influence of the ligand chelate effect on iron-amine-catalysed Kumada cross-coupling

Robin B. Bedford,  Peter B. Brenner, David Elorriaga, Jeremy, N. Harvey and Joshua Nunn, Dalton Trans. doi: 10.1039/C6DT01823H

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Palladium-Catalyzed Ortho-Arylation of Carbamate-Protected Estrogens

Robin B. Bedford, Peter B. Brenner, Steven J. Durrant, Timothy Gallagher, Carolina Meńdez-Gálvez and Michelle Montgomery, J. Org. Chem. doi:  10.1021/acs.joc.6b00532 estrone arylation

Copper-Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β-and γ-Amino­alkyl)boronic Esters

Nina Ursinyova, Robin B. Bedford and Timothy Gallagher, Eur. J. Org. Chem. doi: 10.1002/ejoc.201501492

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2015

Catalyst-Switchable Regiocontrol in the Direct Arylation of Remote C-H Groups in Pyrazolo[1,5-a]pyrimidines

Robin B. Bedford, Steven J. Durrant, and Michelle Montgomery, Angew. Chem. Int. Ed. 2015, 54, DOI: 10.1002/anie.201502150

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How Low Does Iron Go? Chasing the Active Species in Fe-Catalyzed Cross-Coupling Reactions

Robin B. Bedford, Acc. Chem. Res. 2015, 48, 1485–1493, special issue “Earth Abundant Metals in Homogeneous Catalysis“

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Facile Hydrolysis and Alcoholysis of Palladium Acetate

Robin B. Bedford, John G. Bowen, Russell B. Davidson, Mairi F. Haddow, Annabelle E. Seymour-Julen, Hazel A. Sparkes,and Ruth L. Webster, Angew. Chem. Int. Ed. 2015, 54, 6591-6594
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Towards Iron-Catalysed Suzuki Biaryl Cross-Coupling: Unusual Reactivity of 2-Halobenzyl Halides

Robin B. Bedford, Timothy Gallagher, Dominic R. Pye, William Savage, Synthesis 2015, 47, 1761–1765, Special issue on “Iron in Organic Synthesis”

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The Development of Iron Catalysts for Cross-Coupling Reactions

Robin B. Bedford and Peter B. Brenner, Top. Organomet. Chem., DOI: 10.1007/3418_2015_99

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2014

Iron-Catalyzed Borylation of Alkyl, Allyl, and Aryl Halides: Isolation of an Iron(I) Boryl Complex

Robin B. Bedford, Peter B. Brenner, Emma Carter, Timothy Gallagher, Damien M. Murphy, and Dominic R. Pye, Organometallics, 2014, 33, 5940–5943

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Catalytic and Organometallic Chemistry of Earth-Abundant Metals

Martin Albrecht, Robin Bedford and Bernd Plietker, Organometallics 2014, 33, 5619−562. Editorial for special issue of Organometallics.

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Iron-phosphine catalyzed cross-coupling of tetraorganoborates and related group 13 nucleophiles with alkyl halides

Robin. B. Bedford, Peter. B. Brenner, Emma Carter, Jamie Clifton, Paul M. Cogswell, Nicholas J. Gower, Mairi F. Haddow, Jeremy N. Harvey, Jeffry A. Kehl, Damien M. Murphy, Emily C. Neeve, Michael L. Neidig, Joshua Nunn, Benjamin E. R. Snyder and Joseph Taylor, Organometallics, 2014, 33, 5767-5780

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Expedient iron-catalyzed coupling of alkyl, benzyl and allyl halides with arylboronic esters

Robin. B. Bedford, Peter B. Brenner, Emma Carter, Thomas W. Carvell, Paul M. Cogswell, Timothy Gallagher, Jeremy N. Harvey, Damien M. Murphy, Emily C. Neeve, Joshua Nunn and Dominic R. Pye, Chem. Eur. J. 2014, 20, 7935-7938.

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Organometallics Roundtable 2013-2014

J. A. Gladysz, R. B. Bedford, M. Fujita, F. P. Gabbaï, K. I. Goldberg, P. L. Holland, J. L. Kiplinger, M. J. Krische, J. Louie, C. C. Lu, J. R. Norton, M. A. Petrukhina, T. Ren, S. S. Stahl, T. D. Tilley, C. E. Webster, M. C. White and G. T. Whiteker, Organometallics, 2014, 33, 1505-1527 (roundtable discussion on the current state of the field and the art in organometallic chemistry, with leading players in the community).

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TMEDA in Iron-Catalyzed Kumada Coupling: Amine Adduct versus Homoleptic “ate” Complex Formation

Robin. B. Bedford, Peter B. Brenner, Emma Carter, Paul M. Cogswell, Mairi F. Haddow, Jeremy N. Harvey, Damien M. Murphy, Joshua Nunn and Christopher H. Woodall, Angew. Chem. Int. Ed. 2014, 53, 1804-1808.

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2013

Synthesis of murrayaquinone A and analogues via ring-closing C-H arylation

Robin B. Bedford, John G. Bowen and Amanda L. Weeks, Tetrahedron, 2013, 69, 4389-4394 (invited article for ‘Symposium in Print’: Metal-Catalyzed C-H Bond Functionalization).

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Simplifying Iron–Phosphine Catalysts for Cross-Coupling Reactions

Robin B. Bedford, Emma Carter, Paul M. Cogswell, Nicholas J. Gower, Mairi F. Haddow, Jeremy N. Harvey, Damien M. Murphy, Emily C. Neeve and Joshua Nunn, Angew. Chem. Int. Ed. 2013, 52, 1285-1288 (highlighted in SynFacts).

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2012

Iron(I) in Negishi Cross-Coupling Reactions

Christopher J. Adams, Robin B. Bedford, Emma Carter, Nicholas J. Gower, Mairi F. Haddow, Jeremy N. Harvey, Michael Huwe, M. Ángeles Cartes, Stephen M. Mansell, Carla Mendoza, Damien M. Murphy, Emily C. Neeve and Joshua Nunn, J. Am. Chem. Soc. 2012, 134, 10333-10336 (No. 1 ‘Most Read’ article, July 2012).

Fe(I)

Exploiting Boron–Zinc Transmetallation for the Arylation of Benzyl Halides: What are the Reactive Species?

Robin B. Bedford, Nicholas J. Gower, Mairi F. Haddow, Jeremy N. Harvey, Joshua Nunn, Rukeme A. Okopie and Rosalind F. Sankey, Angew. Chem. Int. Ed. 2012, 51, 5435-5438.

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2011

Chiral palladacycles based on resorcinol monophosphite ligands: the role of the meta-hydroxyl in ligand C–H activation and catalysis

Robin B. Bedford, Yu-Ning Chang, Mairi F. Haddow and Claire L. McMullin, Dalton Trans., 2011, 40, 9042-9050 (invited paper, special issue on Pincers and other hemilabile ligands).

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Tuning ligand structure in chiral bis(phosphite) and mixed phosphite-phosphinite PCP-palladium pincer complexes

Robin B. Bedford, Yu-Ning Chang, Mairi F. Haddow and Claire L. McMullin, Dalton Trans., 2011, 40, 9034-9041 (invited paper, special issue on Pincers and other hemilabile ligands).

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Mild C-H Halogenation of Anilides and the Isolation of an Unusual Palladium(I)–Palladium(II) Species

Robin B. Bedford, Mairi F. Haddow, Charlotte J. Mitchell and Ruth L. Webster, Angew. Chem. Int. Ed. 2011, 50, 5524-5527 (Angewandte ‘Very Important Paper’).

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Remarkably reactive dihydroindoloindoles via palladium-catalysed dearomatisation

Robin B. Bedford, Natalie Fey, Mairi F. Haddow and Rosalind F. Sankey, Chem. Commun., 2011, 47, 3649-3651.

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2010

Solvent-free aromatic C-H functionalisation/halogenation reactions

Robin B. Bedford, Jens U. Engelhart, Mairi F. Haddow, Charlotte J. Mitchell and Ruth L. Webster, Dalton Trans.,  2010, 39, 10464-10472 (invited paper for special issue covering Dalton Discussion 12).

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Solvent Free Catalytic C-H Functionalisation

R. B. Bedford,* R. L. Webster and C. J. Mitchell, Chem. Commun., 2010, 46, 3095.

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